Polymer Electrode Array

Type: Electrophysiology / Probes,

Keywords: Polymer electrode, Multielectrode recording, Modular recording, BRAIN Initiative

Very large scale multielectrode recording—flexible, biocompatible polymer electrodes

We have developed a modular recordings system with soft, flexible polymer electrodes that makes it possible to record from hundreds of neurons distributed across many brain areas, and to do so for many months. We are currently distributing these electrodes to ~20 other labs for testing, and their feedback will be used to further refine the devices. Our long term goal is to be able to disseminate these devices to the entire community.

* Developed a new set of flexible, biocompatible polymer electrodes, new electronics, new software and new surgical approaches that are making it possible to record from up to 1024 electrodes simultaneously
* Yielding high quality recordings from hundreds of neurons distributed across multiple brain regions in behaving animals
* Able to extend these recordings for many months, as well as to record continuously for 24 hours a day, 7 days a week

* Monitoring the activity of populations of neurons across brain structures across days.

* Long lasting recordings from neurons in awake, behaving animals

* Rat (demonstrated); mouse, songbird, primate (in progress)

* Very long lasting, stable recordings from multiple brain regions

* See JOVE article

CONTACT NAME, POSITION

Loren Frank, Professor

ORGANIZATION

UCSF

CONTACT INFORMATION

TEAM

Peter Denes (LBNL)
Kris Bouchard (LBNL)
Allison Yorita (LLNL)
Razi Haque (LLNL)
Mattias Karlsson (SpikeGadgets)
Magnus Karlsson (SpikeGadgets)
Beth Buffalo (UW)
Michael Brainard (UCSF)
Alexandra Nelson (UCSF)

LAB WEBSITE(S)

COLLABORATOR(S)

Peter Denes (LBNL)
Kris Bouchard (LBNL)
Allison Yorita (LLNL)
Razi Haque (LLNL)
Mattias Karlsson (SpikeGadgets)
Magnus Karlsson (SpikeGadgets)
Beth Buffalo (UW)
Michael Brainard (UCSF)
Alexandra Nelson (UCSF)

GRANT SUPPORT / FUNDING SOURCE

UC Lab Fees Program LF-12-237680, NIH U01 NS090537, UF1 NS107667