Neurobiology in Changing Ecosystems (NiCE)

ISSUED BY: The Kavli Foundation


Understanding the neurobiological mechanisms that underlie neural, physiological, and behavioral responses to anthropogenic environmental change is of vital importance in today’s rapidly evolving world. The nervous system serves as an interface between an organism and its environment, and through it, perceives, responds, and adapts to change. Anthropogenic stressors such as noise pollution, ocean acidification, chemical pollution, temperature fluctuation and other human-generated environmental perturbations pose severe threats to organisms, thereby affecting biodiversity and ecosystem services. Research in the area of neurobiology in changing ecosystems holds promise to reveal novel scientific insights that will contribute to understanding neural adaptation and resilience at molecular, biophysical, cellular, and circuit level (Michaiel and Bernard 2022; O’Donnell 2018). To investigate the dynamic relationship between the nervous system and environments in flux, it is essential that research combines multidisciplinary expertise. Collaboration between neuroscientists, environmental scientists, molecular biologists, animal behaviorists, marine biologists, ecologists, and climate scientists will promote an integrative and comprehensive approach to understanding neurobiological processes that mediate organismal adaptation and resilience.

Opportunities for investigation of neurobiology and changing ecosystems specifically cover modulatory, homeostatic, adaptive, and/or evolutionary mechanisms that impact neurophysiology in response to anthropogenic environmental influence. To address an unmet need, a focus on fundamental basic research topics in cell and circuit-based approaches is required, rather than on environmental sustainability applications, ecological impacts or human health outcomes – which, while critical, are being addressed through other funding mechanisms.

With this Dear Colleague Letter (DCL), programs in the National Science Foundation’s (NSF) Directorate for Biological Sciences’ (BIO) Division for Integrative Organismal Systems (IOS) and The Kavli Foundation’s Neurobiology and Changing Ecosystems Initiative encourage submission of research proposals that advance the field of neurobiology in changing ecosystems during fiscal year 2024 (through September 30, 2024). The opportunity described in this DCL encourages proposals that emphasize interdisciplinary collaborations and integrate diverse methodologies, including environmental monitoring techniques, behavioral and physiological experiments, ecological and evolutionary modeling, combined with traditional approaches in neuroscience investigation.

NiCE proposals should explicitly address the following three criteria:

  • The importance, extent, or urgency of the anthropogenic environmental change being investigated.
  • The relationship between the neural mechanisms under investigation and the organism’s fitness in the changing environment.
  • How the results of the project will inform or predict resilience in related neural mechanisms, organisms, or environments.


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    General Information:


    NSF 24-044




    December 22, 2023


    January 1, 1970


    March 1, 2025