Topographic organization of projections from the basal ganglia. a) Experimental protocol for studying topography in the basal ganglia. First, AAV1-Cre is injected into dorsal medial striatum (DMS), dorsal lateral striatum (DLS), or ventral lateral striatum (VLS) of H2B-EGFP reporter mice. After 2 weeks, the Cre encoded by the virus activates H2B-EGFP expression. b) Example sections of the striatum showing the injection sites. c) Example section (left column) and average relative cell density map of H2B-EGFP-expressing cells (right column) in globus pallidus externus (GPe; left), entopeduncular nucleus (EP; middle) and substantia nigra pars reticulata (SNr; right) for injections at three different striatal sites (top, DMS; middle, DLS; bottom, VLS).
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